Brønsted acid-catalyzed reaction of alkynyltrifluoroborates with acetals and ketals
| dc.contributor.advisor | Bolshan, Yuri | |
| dc.contributor.author | Baxter, Matthew | |
| dc.date.accessioned | 2015-05-27T15:15:21Z | |
| dc.date.accessioned | 2022-03-29T17:06:02Z | |
| dc.date.available | 2015-05-27T15:15:21Z | |
| dc.date.available | 2022-03-29T17:06:02Z | |
| dc.date.issued | 2015-04-01 | |
| dc.degree.discipline | Applied Bioscience | en |
| dc.degree.level | Master of Science (MSc) | en |
| dc.description.abstract | The synthesis of small molecules is crucial in the pharmaceutical industry for producing drugs or biologically active compounds. Specifically, the formation of new carbon-carbon bonds is of great importance in synthetic organic chemistry. Brønsted acid catalysis is a powerful synthetic tool to make many different compounds, however, the current carbon-based nucleophiles are the major limitation of acid-catalyzed reactions. In effort to expand repertoire of Brønsted acid compatible nucleophiles, we present a novel carbon-carbon bond forming methodology between acetals, ketals, and potassium phenylacetylene trifluoroborate salts. Excellent functional group tolerance is observed with this protocol including, halogen, nitrile, nitro, acid and carbonyl functionalities. | en |
| dc.description.sponsorship | University of Ontario Institute of Technology | en |
| dc.identifier.uri | https://hdl.handle.net/10155/528 | |
| dc.language.iso | en | en |
| dc.subject | Brønsted | en |
| dc.subject | Alkynyltrifluoroborates | en |
| dc.subject | Acetals | en |
| dc.subject | Ketals | en |
| dc.subject | Acid | en |
| dc.title | Brønsted acid-catalyzed reaction of alkynyltrifluoroborates with acetals and ketals | en |
| dc.type | Thesis | en |