Neuroimaging metrics of drug- and food-cue reactivity as a function of psychopathic traits, substance use, and substance dependence
| dc.contributor.advisor | Shane, Matthew S. | |
| dc.contributor.author | Denomme, William James | |
| dc.date.accessioned | 2018-08-30T18:58:59Z | |
| dc.date.accessioned | 2022-03-29T17:43:19Z | |
| dc.date.available | 2018-08-30T18:58:59Z | |
| dc.date.available | 2022-03-29T17:43:19Z | |
| dc.date.issued | 2018-08-01 | |
| dc.degree.discipline | Forensic Psychology | en |
| dc.degree.level | Master of Science (MSc) | en |
| dc.description.abstract | We conducted two fMRI studies assessing the relationship between psychopathy and drug- and food-related neural reactivity. In the first study, we assessed the relationship between psychopathic traits and neural reactivity among 47 cocaine-dependent and 58 non-dependent participants. The cocaine-dependent group exhibited a neural processing bias towards drugrelated stimuli within a corticolimbic circuit involved in decision-making, salience attribution, and motivation. Psychopathic traits both sensitized this neural processing bias and modulated the effect of substance use severity. In the second study, we separated dependent participants into psychologically- (n =25) or physiologically-dependent (n = 20) participants and observed a neural processing bias towards drug-related stimuli among physiologically-dependent participants alone. Interestingly, both psychopathic traits and substance use severity exhibited positive correlations to drug > food reactivity within psychologically-dependent participants. These results further our understanding of the comorbidity between psychopathy and addiction and help conceptualize a new comprehensive model for the development of addiction. | en |
| dc.description.sponsorship | University of Ontario Institute of Technology | en |
| dc.identifier.uri | https://hdl.handle.net/10155/948 | |
| dc.language.iso | en | en |
| dc.subject | Addiction | en |
| dc.subject | Psychopathy | en |
| dc.subject | fMRI | en |
| dc.subject | Neural processing | en |
| dc.subject | Corticolimbic | en |
| dc.title | Neuroimaging metrics of drug- and food-cue reactivity as a function of psychopathic traits, substance use, and substance dependence | en |
| dc.type | Thesis | en |