Response of salivary IL-8 to prolonged and interrupted sitting
dc.contributor.advisor | Dogra, Shilpa | |
dc.contributor.author | O’Rourke, Nicholas | |
dc.date.accessioned | 2022-08-29T19:31:56Z | |
dc.date.available | 2022-08-29T19:31:56Z | |
dc.date.issued | 2022-08-01 | |
dc.degree.discipline | Kinesiology | |
dc.degree.level | Master of Health Sciences (MHSc) | |
dc.description.abstract | The effect of prolonged sitting on inflammation, as determined by cytokine profiles, is relatively unexplored. The purpose of this work was to determine the reliability of salivary IL-8 (CXCL8) and the response of IL-8 to prolonged and interrupted sitting. Participants completed two sessions in random order: prolonged sitting (4 hours of sitting) and interrupted sitting (prolonged sitting interrupted every 30 minutes by 3 minutes of walking). Saliva and capillary plasma samples were collected pre- and post-session. Weekly variability in salivary IL-8 and individual responses were also explored. Prolonged sitting increased salivary IL-8 concentrations, while interrupted sitting attenuated this response. Among males, there was no increase in salivary IL-8 during interrupted sitting. Prolonged sitting may serve as a pro-inflammatory stimulus, and movement interruptions may negate this response. Saliva sampling seems to be a reliable method in assessing IL-8 across timepoints within individuals; however, there is high variability across individuals. | en |
dc.description.sponsorship | University of Ontario Institute of Technology | en |
dc.identifier.uri | https://hdl.handle.net/10155/1499 | |
dc.language.iso | en | en |
dc.subject | Sedentary behaviour | en |
dc.subject | Inflammation | en |
dc.subject | Cytokines | en |
dc.subject | Interleukin 8 | en |
dc.subject | Sitting | en |
dc.title | Response of salivary IL-8 to prolonged and interrupted sitting | en |
dc.type | Thesis | en |
thesis.degree.discipline | Kinesiology | |
thesis.degree.grantor | University of Ontario Institute of Technology | |
thesis.degree.name | Master of Health Sciences (MHSc) |